OUR MISSION AND VISION
TO PREVENT AND EFFECTIVELY TREAT ALZHEIMER’S DISEASE
1906
Today
1900-1970
First Discovery
1906
Dr. Alois Alzheimer first diagnosis
Alzheimer’s Disease got the name from Dr. Alois Alzheimer. He first noticed changes in the brain tissue of a woman who had died of an unusual mental illness. Her symptoms included memory loss, language problems, and unpredictable behavior. After she died, he examined her brain and found many abnormal clumps (now called amyloid plaques) and tangled bundles of fibers (now called neurofibrillary, or tau, tangles).
Alzheimer’s Disease got the name from Dr. Alois Alzheimer. He first noticed changes in the brain tissue of a woman who had died of an unusual mental illness. Her symptoms included memory loss, language problems, and unpredictable behavior. After she died, he examined her brain and found many abnormal clumps (now called amyloid plaques) and tangled bundles of fibers (now called neurofibrillary, or tau, tangles).
1906-1970
AD Assumed as Untreatable Degenerative Disease
1974-1986
Emerging Research
1974
Founding of National Institute on Aging (NIA)
The National Institute on Aging (NIA) is established as one of our National Institutes of Health (NIH). The NIA is our primary federal agency supporting Alzheimer’s research.
1976
“The Prevalance and Malignancy of Alzheimer’s Disease” In Journal Archives of Neurology
In the 10 years preceding his editorial, which called Alzheimer’s a “major killer” and the fourth leading cause of death in the United States (after heart disease, cancer and stroke), fewer than 150 scientific articles had been published about the disease.
Late 1970's
Cholinergic Hypothesis Suggests Treatment Possibilities
1984
Beta-Amyloid Identified as Prime Suspect in Triggering Nerve Cell Damage
BETA-AMYLOID, THE CHIEF COMPONENT OF ALZHEIMER’S BRAIN PLAQUES AND A PRIME SUSPECT IN TRIGGERING NERVE CELL DAMAGE, IS IDENTIFIED BY SAN DIEGO RESEARCHER GEORGE GLENNER.
1986
Tau Protein Identified a Key component of Tangles
This is the second pathological hallmark of Alzheimer’s disease and another prime suspect in nerve cell degeneration.
1987-1994
Steps Toward Treatment
1987
First Encouraging Alzheimer’s Drug Trial
Tacrine – boosts acetylcholine in the brain by interfering with acetylcholine breakdown.
1991
Alzheimer’s Disease Cooperative Study (ADCS) Launched
Funded by NIA and led by Leon Thal.
Photo Credit: Einstein College of Medicine
1993
First Drug Approved
Tacrine is approved; three similar drugs follow.
1994
Former U.S. President Ronald Reagan Alzheimer’s Diagnosis is Announced
2003-2010
Advancement in Technology
2003
Memantine is Approved
Memantine is approved, representing a second therapeutic class for ad.
2004
Nationwide Study Launched to Establish Standards for Obtaining and Interpreting Brain Images
The Alzheimer’s Disease Neuroimaging Initiative (ADNI) was funded by National Institute of Aging (NIA) plus contributions from pharmaceutical companies in 2004 to optimize biomarker assessments in support of AD therapeutic trials. This multicenter project would grow to be conducted across 63 sites studying three cohorts, cognitively normal individuals, those with mild cognitive impairment and those with mild AD dementia, with MRI, lumbar puncture for spinal fluid analysis, and cognitive and clinical assessments longitudinally. Amyloid PET imaging was added to the ADNI protocol in 2005, and tau PET was added in 2015. Remarkably, ADNI shares all data collected as soon as it is quality-controlled; this aggressive data sharing has resulted in over 2000 peer-reviewed publications using ADNI data. The coordinating center for ADNI moved to USC ATRI in 2015. ADNI data has been instrumental to the design of most therapeutic trials in the field. The latest application to continue ADNI has been submitted.
2005
NIA’s Alzheimer’s Disease Preclinical Drug Development Program is Established
2007
PAUL AISEN, MD NAMED NEW DIRECTOR OF ADCS
2010
An Influential Model of Biomarker Changes During Alzheimer’s Disease Progression
2011-2012
Nationalizing AD Prevention
2011
National Alzheimer’s Project Act (NAPA) Signed into Law
2012
Five Ambitious Goals to Prevent Future Cases of AD and Related Dementias
The National Plan establishes five ambitious goals to both prevent future cases of alzheimer’s disease and related dementias (ad/adrd).
1 – Prevent and Effectively Treat Alzheimer’s Disease by 2025.
2 – Optimize Care Quality and Efficiency.
3 – Expand Supports for People with Alzheimer’s Disease and Their Families.
4 – Enhance Public Awareness and Engagement.
5 – Track Progress and Drive Improvement.
2 – Optimize Care Quality and Efficiency.
3 – Expand Supports for People with Alzheimer’s Disease and Their Families.
4 – Enhance Public Awareness and Engagement.
5 – Track Progress and Drive Improvement.
2014-2020
Foundation of ATRI & ACTC
2014
Landmark Antiamyloid Treatment in Asymptomatic AD (A4) Study Launched
A major milestone was the launch of the Anti-Amyloid treatment in Asymptomatic Alzheimer’s (A4) Study. A4 is the first multicenter trial in sporadic preclinical (pre-symptomatic) Alzheimer’s disease (AD). The idea for this project arose from analysis of longitudinal observational data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) that indicated that amyloid elevation in brain in clinically normal individuals is associated with subtle cognitive and biomarker evidence of decline. Thus ‘preclinical AD’ may be the optimal stage at which to intervene with anti- amyloid therapies, with sensitive cognitive tests as well as secondary biomarker measurements as outcomes to establish efficacy. A4 was initially funded as a project of the ADCS. Solanezumab, a monoclonal antibody against monomeric amyloid peptide was selected as the therapeutic, and a public private partnership with Eli Lilly and NIA was established to carry out the trial, with additional funding contributed by philanthropic groups. A4 transitioned to USC ATRI in 2015 and was fully enrolled with 1169 randomized participants across 67 sites by the end of 2017. It will be completed near the end of 2022. In a first for a Phase 3 trial, A4 pre- randomization data, which provides the largest dataset on amyloid accumulation in clinically normal individuals, was publicly released one year after completion of enrollment.
2015
ATRI Founded as a San Diego Institute of USC
The Alzheimer’s Therapeutic Research Institute (ATRI) was founded by Paul S. Aisen, MD and a group of about 40 faculty and staff who had been working together for many years at the Alzheimer’s Disease Cooperative Study (ADCS), which at the time was the primary National Institutes of Health (NIH) funded program conducting clinical trials in Alzheimer’s disease (AD). Located in San Diego and part of the University of Southern California (USC) Keck School of Medicine, the mission of ATRI is to accelerate the development of effective therapies for AD. ATRI was designed to facilitate effective academic-industry collaborations with major administrative support from USC. Its structure is unique among USC institutes. The faculty members, while pursuing their own independent research, are all actively involved in the institute’s primary mission, and so constitute a well-aligned research team. The expertise at ATRI is multidimensional, with world renowned scientists and a research team across multiple disciples working together within a team science environment in the systematic pursuit of establishing the most innovative and collaborative global clinical trials program in AD therapeutics. This highly experienced research team, with expertise in biomarkers, biostatistics, clinical monitoring, clinical operations, finance, informatics, regulatory, recruitment, and medical safety, and an independent Data and Safety Monitoring Board, allows ATRI to efficiently conduct international multicenter clinical trials and other large clinical research studies . The embedded USC human resources and contracting enable efficient large-scale operations.
2016
Alzheimer’s Clinical Consortium (ACTC) Formed
In 2016, NIA released a funding opportunity announcement inviting applications for a new academic network called the Alzheimer’s Clinical Trial Consortium (ACTC). The announcement incorporated many new ideas resulting from the decades of experience in the field, including the value of a central institutional review board, standing support for trial sites and separation of project funding from the parent grant mechanism, among others. The first ACTC grant was awarded to a team of investigators at three institutions, USC, Harvard and the Mayo Clinic.
2020
ATRI Marks 5 Year Anniversary
In the first five years since its formation, ATRI has established itself as a global Alzheimer’s disease research institute conducting high quality research attracting funding from the public and private sectors. The initial team of 40 has grown to include seven faculty with academic appointments at the USC Department of Neurology and approximately 170 research and administrative staff. Major collaborations with the National Institutes of Health (NIH), Alzheimer’s Association and several industry partners make ATRI one of the largest and most successful independent programs, both at USC and elsewhere. ATRI continues to be an evolving enterprise; in terms of clinical trials, grants and publications.
2021-2023
Modern Research
2021
FDA Approved Aduhelm
The U.S. Food and Drug Administration approved Aduhelm (aducanumab) for the treatment of Alzheimer’s, a debilitating disease affecting 6.2 million Americans. Aduhelm was approved using the accelerated approval pathway, which can be used for a drug for a serious or life-threatening illness that provides a meaningful therapeutic advantage over existing treatments. Aduhelm represents a first-of-its-kind treatment approved for Alzheimer’s disease. It is the first new treatment approved for Alzheimer’s since 2003 and is the first therapy that targets the fundamental pathophysiology of the disease. Read more about this historic approval here.
2022
FDA Approves Lecanemab
In January, 2022, U.S. Food and Drug Administration approved Leqembi (lecanemab-irmb) via the Accelerated Approval pathway for the treatment of Alzheimer’s disease. Leqembi is the second of a new category of medications approved for Alzheimer’s disease that target the fundamental pathophysiology of the disease. Read more about this milestone in the ongoing fight to effectively treat Alzheimer’s disease here.
2022
USC & UC San Diego Join Forces in AD Research
A joint gift to USC and the University of California, San Diego, totaling $50 million from the Epstein Family Foundation will drive Alzheimer’s research and accelerate the search for treatments and a cure. The generous donation establishes the Epstein Family Alzheimer’s Research Collaboration at USC and UC San Diego. The gift will be split evenly, with $25 million going to each institution. The funding will support existing research at each university and will spark new collaborative efforts to discover effective therapies for Alzheimer’s disease.
2023
Donanemab Significantly Slowed Cognitive and Functional Decline in Phase 3 Study of Early Alzheimer’s Disease
Donanemab has shown positive results in a Phase 3 clinical trial called TRAILBLAZER-ALZ 2. The study evaluated the safety and effectiveness of the drug that targets amyloid plaques in people with early symptomatic Alzheimer’s disease. Read more about Donanemab’s performance here.
2023
ATRI Expands Scope
In cooperation with Carolyn Meltzer, Dean of the Keck School of Medicine of USC, and Berislav Zlokovic, Director, Zilkha Neurogenetic Institute the Alzheimer’s Therapeutic Research Institute (ATRI) successfully recruited our long-term collaborator Robert Rissman, Director of ATRI Biomarker Laboratory and Biorepository to establish a Neuroscience Translational Research Division. This change greatly expands the scope of ATRI to include basic science translational research in models of disease that can serve as preclinical work for future therapeutics. Read more about Donanemab’s performance here.
2023
Dr. Aisen Honored with Epstein Alzheimer’s Disease Director’s Chair
USC’s Alzheimer’s Therapeutic Research Institute (ATRI) in San Diego hosted the chair installation ceremony, which recognized and honored Dr. Aisen’s decades of work leading teams toward more effective treatments for Alzheimer’s disease.
The Director’s Chair was endowed by the Epstein Family Foundation as another generous gift in a series of significant donations catalyzing Alzheimer’s research in Southern California
The Director’s Chair was endowed by the Epstein Family Foundation as another generous gift in a series of significant donations catalyzing Alzheimer’s research in Southern California
2023
FDA Grants Full Approval to Lecanemab for the Treatment of Alzheimer’s
On July 6, the Food and Drug Administration granted full approval to LEQEMBI (lecanemab) for the treatment of Alzheimer’s disease (AD). According to the current FDA approval, lecanemab should be initiated in patients with mild cognitive impairment or mild dementia. Lecanemab is the first approved treatment shown to slow down the progression of the disease, reduce cognitive decline, and improve daily functioning in adults with AD.
2025-Today
ATRI Renamed
2025
ATRI Renamed to Honor Daniel Epstein and Family
In December 2025, ATRI was renamed the USC Epstein Family Alzheimer’s Therapeutic Research Institute in honor of USC Life Trustee Daniel J. Epstein, his wife Phyllis and their family, the visionary philanthropic leaders fueling USC’s world-leading efforts to prevent and treat Alzheimer’s disease.
In January, 2022, U.S. Food and Drug Administration approved Leqembi (lecanemab-irmb) via the Accelerated Approval pathway for the treatment of Alzheimer’s disease. Leqembi is the second of a new category of medications approved for Alzheimer’s disease that target the fundamental pathophysiology of the disease. Read more about this milestone in the ongoing fight to effectively treat Alzheimer’s disease here.
USC’s Alzheimer’s Therapeutic Research Institute (ATRI) in San Diego hosted the chair installation ceremony, which recognized and honored Dr. Aisen’s decades of work leading teams toward more effective treatments for Alzheimer’s disease.
The Director’s Chair was endowed by the Epstein Family Foundation as another generous gift in a series of significant donations catalyzing Alzheimer’s research in Southern California
The Director’s Chair was endowed by the Epstein Family Foundation as another generous gift in a series of significant donations catalyzing Alzheimer’s research in Southern California